West Ham United striker Javier Hernandez suffered a suspected hamstring injury during Mexico’s 3-3 draw with Belgium on Friday.
Hernandez was forced to leave the field after 51 minutes having won a penalty on his 100th international appearance.
Mexico face another friendly against Poland on Monday.
The injury will be a worry for West Ham’s new manager David Moyes as he prepares for next Sunday’s Premier League game at Watford.
Hernandez is West Ham’s top scorer in the Premier League this season with four goals in 11 appearances, more than a third of their overall total.
The Hammers currently sit in 18th place in the table following six losses, three draws and just two wins.